Hu Autoantibody Test

Recombinant hu antigen staining of protein band control for each serum showing staining is specific.

Hu autoantibody test. Laboratory must have strong clinical validation showing specificity and sensitivity of results positive result by. Specimen requirement is one red top or sst tube of blood. Test serums adsorbed with systemic antigens selective staining of neuronal nuclei.

Hu antibody screen with reflex to titer and western blot paraneoplastic syndrome involves non metastatic systemic effects that accompany malignant disease. Anti hu is associated with subacute syndrome of encephalomyeloradiculopathy sensory neuropathy and autoimmune neuropathy. Anti hu is not recommended as a screening test for lung cancer.

Reference range is 1 60 in serum and 1 2 in csf. Autoantibody tests may be ordered as part of an investigation of chronic progressive arthritis type symptoms and or unexplained fevers fatigue muscle weakness and rashes. Antineuronal antibodies serve as markers that aid in discriminating between a true paraneoplastic neurological disorder pnd and other inflammatory disorders of the nervous system.

Anti hu is detected in 5 to 10 of patients with small cell lung carcinoma who do not have a paraneoplastic syndrome. Automated nanoliter scale immunoassay. Ana is a marker of the autoimmune process it is positive with a variety of different autoimmune diseases but.

The antinuclear antibody ana test is often ordered first. This test detects igg antineuronal antibodies to hu ri yo and tr dner antigens. Purkinje cell yo antibody is found in patients with paraneoplastic cerebellar degeneration and is associated with breast ovarian and other gynecologic cancers.

Hu yo and ri antibodies with reflex to titers and western blot hu anti neuronal nuclear antibody anti hu is found in 5 10 of patients with small cell carcinoma of the lung. The test can also be performed on csf. Also called type 1 antineuronal antibody.